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San Francisco

Python jobs in San Francisco

353 open Python roles at venture-backed startups in San Francisco, across 125 companies, at new grad, mid, senior and stafflevel. Pulled from the companies’ own job boards and refreshed through the day.

Open roles

353
Perplexity logoMember of Technical Staff (AI Software Engineer, Agents)Perplexity · Staff · $220K - $405K→Retell AI logoForward Deployed Engineer, New GradRetell AI · New Grad · $150K - $260K→TRM Labs logoSenior Software Engineer, Data Product · SF OnlyTRM Labs · Senior→Idler logoForward Deployed EngineerIdler · Mid · $125K - $400K→Perplexity logoMember of Technical Staff (Software Engineer, Model Platform)Perplexity · Staff · $220K - $405K→Vapi logoMember of Technical Staff, Agentic Developer ExperienceVapi · Staff→Pharos logoProduct EngineerPharos · Mid→Ditto logoAI EngineerDitto · Mid · $185K - $259K→Zip logoSoftware Engineer, New Grad (2027 Start)Zip · New Grad→Candid Health logoSecurity Engineer, GRCCandid Health · Mid→Benchling logoSoftware Engineer, Platform (Developer Experience)Benchling · Mid · $173K - $234K→Checkr logoSenior Software Engineer (Python), MortgageCheckr · Senior→RADAR logoSenior Systems EngineerRADAR · Senior→Luminai logoSenior Software Engineer, PlatformLuminai · Senior · $170K - $220K→Sierra logoIT Infrastructure EngineerSierra · Mid · $130K - $165K→hud logoFull-Stack Software Engineer, Reinforcement Learninghud · Mid→Mixpanel logoDelivery Engineer IIMixpanel · Mid→Swayable logoSenior AI/ML Engineer: Python & Scientific ComputingSwayable · Senior→Firecrawl logoMachine Learning EngineerFirecrawl · Mid · $210K - $240K→Baseten logoAI EngineerBaseten · Mid · $220K - $260K→Faire logoSenior Staff Machine Learning Platform EngineerFaire · Staff→Haladir logoFounding Operations Research Engineer (Full Time)Haladir · Mid · $150K - $220K→Knowtex logoML Engineer: Speech & LLMsKnowtex · Mid→Notion logoSoftware Engineer, New Grad (Dec 2026)Notion · New Grad→Gusto logoSenior Data EngineerGusto · Senior→FurtherAI logoStaff Product EngineerFurtherAI · Staff · $250K - $400K→Fivetran logoSenior Software Engineer · MetadataFivetran · Senior→Baseten logoSoftware Engineer · AI Developer ProductivityBaseten · Mid · $165K - $330K→Baseten logoSoftware Engineer · Testing FrameworksBaseten · Mid · $165K - $330K→Baseten logoSoftware Engineer · Continuous DeliveryBaseten · Mid · $165K - $330K→Luminai logoForward Deployed Engineer, Team LeadLuminai · Senior · $190K - $270K→Vorticity logoSoftware Engineer, Parallel Scientific ComputingVorticity · Mid · $130K - $190K→Baseten logoSoftware Engineer · ObservabilityBaseten · Mid · $165K - $330K→Fivetran logoStaff Software Engineer, MetadataFivetran · Staff→Gusto logoSoftware Engineer, ML PlatformGusto · Mid→Faire logoStaff Engineer · Experimentation PlatformFaire · Staff→AfterQuery logoSWE (LATM)AfterQuery · Mid · $84K - $120K→Teleport logoStaff Data Engineer · USTeleport · Staff · $222K - $342K→Apollo.io logoPrincipal Software Engineer (Hybrid, San Francisco)Apollo.io · Principal→One Robot logoFounding Machine Learning · World ModelsOne Robot · Mid · $150K - $275K→One Robot logoFounding Machine Learning · Eval LayerOne Robot · Mid · $150K - $275K→Apollo.io logoSenior Software Engineer (Hybrid, San Francisco)Apollo.io · Senior→Decagon logoIT EngineerDecagon · Mid · $96K - $140K→Stage logoSoftware Engineer · Investment SystemsStage · Mid→Astranis logoSoftware Engineer · Hardware TestAstranis · Mid→Observe.AI logoAI Agent Engineer, Client FacingObserve.AI · Mid→Baseten logoAI Inference EngineerBaseten · Mid · $165K - $330K→Retell AI logoApplied AI Engineer (Customer Facing)Retell AI · Mid · $180K - $300K→Faire logoSenior Applied ML/AI Scientist · SearchFaire · Senior→LiteLLM logoFounding Developer RelationsLiteLLM · Mid · $150K - $220K→LiteLLM logoAI EngineerLiteLLM · Mid · $200K - $250K→Faire logoSenior Enterprise Security EngineerFaire · Senior→Metriport logoSenior Data EngineerMetriport · Senior · $180K - $220K→Metriport logoStaff Data EngineerMetriport · Staff · $200K - $260K→Metriport logoStaff Software EngineerMetriport · Staff · $200K - $260K→Ansa Biotechnologies logoSystems Integration EngineerAnsa Biotechnologies · Mid→hud logoLead Research Engineer, Data Qualityhud · Senior→Decagon logoEngineering Manager, Agent ProductDecagon · Mid · $280K - $430K→Compresr logoFounding EngineerCompresr · Mid→LiteLLM logoStaff EngineerLiteLLM · Staff · $240K - $270K→

Python elsewhere

Python jobs in New YorkPython jobs in Remote (US)Python jobs in Los AngelesPython jobs in Seattle

Also hiring in San Francisco

TypeScriptReactAWSKubernetesLLMGoNodeRustPostgresGraphQL

Questions

How many Python jobs are open in San Francisco?

353 right now, across 125 venture-backed companies. The list comes from company job boards and refreshes several times a day, so it reflects what is genuinely open rather than a snapshot from last quarter.

What levels are hiring?

new grad, mid, senior and staff. Every role links through to the full description and the company behind it.

Do I have to apply to each one?

No. Drop your resume once, and we put a short list in front of you. Your name and resume reach a company only for the roles you mark interested, and we introduce you rather than adding you to an application pile.

Want these without checking a board.

Drop your resume once. We read it properly, put the roles that fit in front of you, and introduce you only where you say yes.

Drop your resume